abstract：RESEARCH QUESTION:Can women be identified, on the basis of baseline patient characteristics, as having better chances of an ongoing pregnancy with FSH instead of clomiphene citrate as stimulation agent in intrauterine insemination for unexplained subfertility? DESIGN:A secondary analysis of a multicentre randomized co...

journal_title：Reproductive biomedicine online

authors： Danhof NA,van Eekelen R,Repping S,Mol BWJ,van der Veen F,van Wely M,Mochtar MH,SUPER Study group.

更新日期：2019-06-01 00:00:00

abstract：RESEARCH QUESTION:The family with sequence similarity 175 member A gene (FAM175A; also known as ABRAXAS1, CCDC98 and ABRA1), a member of the DNA repair family, contributes to the BRCA1 (BRCA1 DNA repair associated)-dependent DNA damage response and is associated with age at natural menopause. However, it remains poorly...

journal_title：Reproductive biomedicine online

authors： Xu X,Zhang Y,Zhao S,Bian Y,Ning Y,Qin Y

更新日期：2019-06-01 00:00:00

abstract：RESEARCH QUESTION:What is the relationship between the vaginal microbiota profile at the time of embryo transfer and live birth rates in women undergoing IVF/intracytoplasmic sperm injection (ICSI) with donated oocytes? DESIGN:One hundred and fifty Caucasian women receiving donated oocytes were prospectively included ...

journal_title：Reproductive biomedicine online

authors： Vergaro P,Tiscornia G,Barragán M,García D,Rodriguez A,Santaló J,Vassena R

更新日期：2019-06-01 00:00:00

abstract：RESEARCH QUESTION:The prevalence of infertility in couples actively trying to conceive is 25%. What is the consultation-seeking behaviour, diagnosis and related treatment in infertile couples across China? DESIGN:Large cross-sectional population-based study in 2010-2011, in which 25,270 couples from eight provinces/mu...

journal_title：Reproductive biomedicine online

authors： Zheng D,Zhou Z,Li R,Wu H,Xu S,Kang Y,Cao Y,Chen X,Zhu Y,Xu S,Chen ZJ,Mol BW,Qiao J

更新日期：2019-06-01 00:00:00

abstract：RESEARCH QUESTION:What is the incidence, origin and clinical significance of blastomere movement after the first cell division in the human embryo? DESIGN:A total of 1096 embryos, cultured in the EmbryoScope+ ® time-lapse system and subjected to a single fresh cleaved embryo transfer, were retrospectively analysed. Ty...

journal_title：Reproductive biomedicine online

authors： Ezoe K,Ohata K,Morita H,Ueno S,Miki T,Okimura T,Uchiyama K,Yabuuchi A,Kobayashi T,Montag M,Kato K

更新日期：2019-05-01 00:00:00

abstract：RESEARCH QUESTION:Is embryonic morphological development according to the Carnegie stages associated with pregnancy outcome? DESIGN:In a tertiary hospital-based cohort, 182 singleton non-malformed pregnancies were selected. Serial transvaginal three-dimensional ultrasound (3D-US) scans were carried out between 6+0 and...

journal_title：Reproductive biomedicine online

authors： Parisi F,Rousian M,Koning AHJ,Willemsen SP,Steegers EAP,Steegers-Theunissen RPM

更新日期：2019-04-01 00:00:00

abstract：RESEARCH QUESTION:Are self-reported symptoms of stress and depression associated with pregnancy outcomes within the first year after referral to a tertiary recurrent pregnancy loss unit? DESIGN:Prospective cohort study with online questionnaires using the Major Depression Inventory (MDI) and Cohen's Stress Scale (PSS)...

journal_title：Reproductive biomedicine online

authors： Kolte AM,Olsen LR,Christiansen OB,Schmidt L,Nielsen HS

更新日期：2019-04-01 00:00:00

abstract：RESEARCH QUESTION:Does mode of conception influence placental volume and other first-trimester outcomes? DESIGN:This retrospective single-centre case-control study led in Dijon University Hospital included 252 singleton pregnancies (84 IVF with either fresh embryo transfer or frozen-thawed embryo transfer [FET] and 16...

journal_title：Reproductive biomedicine online

authors： Choux C,Ginod P,Barberet J,Rousseau T,Bruno C,Sagot P,Astruc K,Fauque P

更新日期：2019-04-01 00:00:00

abstract：RESEARCH QUESTION:What temperature is optimal for human embryo development up to day 5 or 6? DESIGN:Two prospective sibling oocyte studies on culture temperature were conducted in a university-based tertiary referral centre. Eligibility critera for both studies: Study 1: 50 cycles between August and October 2015, with...

journal_title：Reproductive biomedicine online

authors： Neelke M,Ronny J,Samuel SR,Herman T,Hilde VV,Greta V

更新日期：2019-04-01 00:00:00

abstract：RESEARCH QUESTION:What is the incidence and origin of meiotic whole and segmental aneuploidies detected by karyomapping at a blastocyst stage in human-derived IVF embryos? What is the distribution of various types of errors, including rare chromosomal abnormalities? DESIGN:The incidence of chromosomal aneuploidies was...

journal_title：Reproductive biomedicine online

authors： Kubicek D,Hornak M,Horak J,Navratil R,Tauwinklova G,Rubes J,Vesela K

更新日期：2019-03-01 00:00:00

abstract：:Available evidence on the impact of ovarian stimulation on the progression of endometriosis or its recurrence was systematically reviewed. Data from ovarian stimulation alone, or associated with intrauterine insemination (IUI) or IVF, were included. Sixteen studies were selected. Initial case reports (n = 11) document...

journal_title：Reproductive biomedicine online

authors： Somigliana E,Viganò P,Benaglia L,Busnelli A,Paffoni A,Vercellini P

更新日期：2019-02-01 00:00:00

abstract：RESEARCH QUESTION:Can a combination of time-lapse morphokinetic parameters and cumulus cell gene expression in polycystic ovary syndrome (PCOS) women be used to predict assisted reproductive treatment outcome? DESIGN:A total of 547 embryos from 100 intracytoplasmic sperm injection (ICSI) cycles were evaluated. Fifty w...

journal_title：Reproductive biomedicine online

authors： Tabibnejad N,Sheikhha MH,Ghasemi N,Fesahat F,Soleimani M,Aflatoonian A

更新日期：2019-02-01 00:00:00

abstract：RESEARCH QUESTION:Does the composite morphology score or a particular developmental component (expansion stage, inner cell mass [ICM] or trophectoderm [TE]) of euploid blastocysts undergoing single frozen embryo transfer (FET) impact ongoing pregnancy/live birth (OP/LB) rates? DESIGN:Retrospective cohort study includi...

journal_title：Reproductive biomedicine online

authors： Nazem TG,Sekhon L,Lee JA,Overbey J,Pan S,Duke M,Briton-Jones C,Whitehouse M,Copperman AB,Stein DE

更新日期：2019-02-01 00:00:00

abstract：RESEARCH QUESTION:Elective single-embryo transfer (eSET) at blastocyst stage is widely used to reduce the frequency of multiple pregnancies after IVF. There are, however, concerns about increased risks for the offspring with prolonged embryo culture. Is it possible to select embryos for transfer at the early cleavage s...

journal_title：Reproductive biomedicine online

authors： Vaegter KK,Berglund L,Tilly J,Hadziosmanovic N,Brodin T,Holte J

更新日期：2019-01-01 00:00:00

abstract：RESEARCH QUESTION:Previous studies of aromatase inhibitors on male infertility have focused on men with low testosterone-oestradiol ratio of less than 10. Can aromatase inhibitors improve spermatogenesis in men with idiopathic male infertility with normal testosterone-oestradiol ratio? DESIGN:Prospective study of men ...

journal_title：Reproductive biomedicine online

authors： Shuling L,Sie Kuei ML,Saffari SE,Jiayun Z,Yeun TT,Leng JPW,Viardot-Foucault V,Nadarajah S,Chan JKY,Hao TH

更新日期：2019-01-01 00:00:00

abstract：RESEARCH QUESTION:We recently reported that blocking of placental aquaporins (AQP) abrogates the apoptotic response of the trophoblast. As trophoblast apoptosis is exacerbated in pre-eclampsia, we hypothesized that changes in AQP in these placentae may trigger programmed cell death. We analysed AQP4 expression in pre-e...

journal_title：Reproductive biomedicine online

authors： Szpilbarg N,Seyahian A,Paola MD,Castro-Parodi M,Martinez N,Farina M,Damiano AE

更新日期：2018-11-01 00:00:00

abstract：RESEARCH QUESTION:Does regular smoking affect semen quality and the levels of DNA methylation in mature human spermatozoa? DESIGN:Spermatozoa from 109 men were evaluated (55 smokers and 54 non-smokers). DNA was extracted from purified spermatozoa, and DNA methylation was quantified by enzyme-linked immunosorbent assay...

journal_title：Reproductive biomedicine online

authors： Hamad MF,Dayyih WAA,Laqqan M,AlKhaled Y,Montenarh M,Hammadeh ME

更新日期：2018-11-01 00:00:00

abstract：:In December 2017, Alain Pottage published an article denying the patentability of a technique called Time-Lapse Monitoring (TLM). His argument was that this procedure, like all other embryo selection procedures, fails to respect human dignity. Here, we argue that this statement is mistaken because assisted reproductiv...

journal_title：Reproductive biomedicine online

authors： Beriain IM,Sanz B

更新日期：2018-10-01 00:00:00

abstract：:Preimplantation genetic screening for aneuploidy continues to excite disagreement, discussion and confusion in the field of reproductive medicine. This commentary provides a contribution to the ongoing debate. ...

journal_title：Reproductive biomedicine online

authors： Braude P

更新日期：2018-08-01 00:00:00

abstract：RESEARCH QUESTION:Are maternal concentrations of human chorionic gonadotropin (HCG) on a fixed day after embryo transfer associated with duration of pregnancy? DESIGN:A follow-up study of 1917 singleton pregnancies after IVF was performed. Embryos were cultured for 2 days and maternal HCG concentration quantified on d...

journal_title：Reproductive biomedicine online

authors： Tanbo TG,Zucknick M,Eskild A

更新日期：2018-08-01 00:00:00

abstract：RESEARCH QUESTION:What are the metabolic characteristics of homocysteine in polycystic ovary syndrome (PCOS)? DESIGN:Homocysteine concentrations were determined in serum samples from non-obese and obese control subjects and PCOS patients. Homocysteine metabolism was studied in a rat model of PCOS established using deh...

journal_title：Reproductive biomedicine online

authors： Li D,Liu HX,Fang YY,Huo JN,Wu QJ,Wang TR,Zhou YM,Wang XX,Ma XX

更新日期：2018-08-01 00:00:00

abstract：RESEARCH QUESTION:Does music therapy help in reducing pain and anxiety in women undergoing transvaginal ultrasound-guided oocyte retrieval (TUGOR)? DESIGN:In this randomized controlled open label study, 209 participants were recruited and randomized into three groups (music group, n = 70; headphone group, n = 70; cont...

journal_title：Reproductive biomedicine online

authors： Cheung CWC,Yee AWW,Chan PS,Saravelos SH,Chung JPW,Cheung LP,Kong GWS,Li TC

更新日期：2018-08-01 00:00:00

abstract：RESEARCH QUESTION:What is the molecular basis of infertility related to uterine dysfunction in women with polycystic ovary syndrome (PCOS)? DESIGN:In this study, differences in protein expression between PCOS and normal endometrium were identified using a proteomic approach based on two-dimensional electrophoresis (2-...

journal_title：Reproductive biomedicine online

authors： Amjadi F,Mehdizadeh M,Ashrafi M,Nasrabadi D,Taleahmad S,Mirzaei M,Gupta V,Salekdeh GH,Aflatoonian R

更新日期：2018-08-01 00:00:00

abstract：RESEARCH QUESTION:From a clinical perspective, which parameters grant optimal cryopreservation of mouse testicular cell suspensions? DESIGN:We studied the effect of different cryopreservation rates, the addition of sugars, different vessels and the addition of an apoptotic inhibitor on the efficiency of testicular cel...

journal_title：Reproductive biomedicine online

authors： Onofre J,Faes K,Kadam P,Vicini E,van Pelt AMM,Goossens E

更新日期：2018-07-01 00:00:00

abstract：RESEARCH QUESTION:A number of live-birth predictive models are available, and despite clinical interest these are rarely used owing to poor performance. In addition, no predictive models specifically for poor ovarian responders (POR) are available. The aim of the current project was to develop a clinically applicable t...

journal_title：Reproductive biomedicine online

authors： Lehert P,Chin W,Schertz J,D'Hooghe T,Alviggi C,Humaidan P

更新日期：2018-07-01 00:00:00

abstract：:This retrospective cohort study of 2051 consecutive fresh non-donor intracytoplasmic sperm injection (ICSI) cycles investigated whether time from oocyte retrieval to denudation, precisely measured and recorded by an operator-independent automated radiofrequency-based system, affected cycle outcome. ICSI cycles were di...

journal_title：Reproductive biomedicine online

authors： Naji O,Moska N,Dajani Y,El-Shirif A,El-Ashkar H,Hosni MM,Khalil M,Khalaf Y,Bolton V,El-Toukhy T

更新日期：2018-07-01 00:00:00

abstract：:This proceedings report presents the outcomes from an international Expert Meeting to establish a consensus on the recommended technical and operational requirements for air quality within modern assisted reproduction technology (ART) laboratories. Topics considered included design and construction of the facility, as...

journal_title：Reproductive biomedicine online

authors： Mortimer D,Cohen J,Mortimer ST,Fawzy M,McCulloh DH,Morbeck DE,Pollet-Villard X,Mansour RT,Brison DR,Doshi A,Harper JC,Swain JE,Gilligan AV

更新日期：2018-06-01 00:00:00

abstract：:Vaginal progesterone via capsule, gel or tablet is the most common route for luteal phase support (LPS) in Europe. Although there is a wealth of data comparing products used at other stages of assisted reproductive technology cycles, there is a lack of systematically identified evidence comparing the wide range of vag...

journal_title：Reproductive biomedicine online

authors： Child T,Leonard SA,Evans JS,Lass A

更新日期：2018-06-01 00:00:00

abstract：:The objectives of this study were to investigate whether anti-Müllerian hormone (AMH) concentrations can predict pregnancy rates and time to pregnancy (TTP) in women attempting to conceive naturally/having an unplanned conception, and whether there is a lower AMH threshold compatible with natural conception. This pros...

journal_title：Reproductive biomedicine online

authors： Korsholm AS,Petersen KB,Bentzen JG,Hilsted LM,Andersen AN,Hvidman HW

更新日期：2018-05-01 00:00:00

abstract：:Embryonic growth is often impaired in miscarriages. It is postulated that derangements in embryonic growth result in abnormalities of the embryonic curvature. This study aims to create first trimester reference charts of the human embryonic curvature and investigate differences between ongoing pregnancies and miscarri...

journal_title：Reproductive biomedicine online

authors： Bogers H,van Uitert EM,van Ginkel S,van der Mooren EDH,Groenenberg IAL,Eilers PHC,Exalto N,Steegers EAP,Steegers-Theunissen RPM

更新日期：2018-05-01 00:00:00

abstract：:The aim of this study was to devise an evidence-based scoring system for prioritizing mosaic aneuploid embryos for transfer. A retrospective analysis was performed of all sequential cytogenetic and molecular results on chorionic villi samples (n = 72,472) and products of conception (n = 3806) analysed at a single cent...

journal_title：Reproductive biomedicine online

authors： Grati FR,Gallazzi G,Branca L,Maggi F,Simoni G,Yaron Y

更新日期：2018-04-01 00:00:00

abstract：:Laparotomic myomectomy is often the only realistic solution for symptomatic women with multiple or large myomas who wish to retain their fertility. The aim of this study was to document the rate of uterine synechiae and their associated risk factors after laparotomic myomectomy. This prospective observational study to...

journal_title：Reproductive biomedicine online

authors： Capmas P,Pourcelot AG,Fernandez H

更新日期：2018-04-01 00:00:00

abstract：:Ovarian stimulation with low-dose human menopausal gonadotrophin (HMG) is superior to clomiphene citrate in intrauterine insemination (IUI) cycles with respect to clinical pregnancy rate, but it is unclear whether HMG is also the more cost-effective option. The aim of this study was to compare the cost-effectiveness o...

journal_title：Reproductive biomedicine online

authors： Peeraer K,Luyten J,Tomassetti C,Verschueren S,Spiessens C,Tanghe A,Meuleman C,Debrock S,Dancet E,D'Hooghe T

更新日期：2018-03-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disease. Previous studies indicate that genes GGT1 and HNF1A may contribute to the abnormal glucose metabolism and altered lipid profile that are important clinical features of PCOS. In the current study, the correlation between polymorphisms in the GGT...

journal_title：Reproductive biomedicine online

authors： Xu X,Qin L,Tian Y,Wang M,Li G,Du Y,Chen ZJ,Li W

更新日期：2018-01-01 00:00:00

abstract：:Time-lapse imaging of the human preimplantation embryo in vitro has revealed a transient phenomenon involving the appearance of perivitelline threads, commonly observed at the two-cell stage. These threads span the perivitelline space, arising at the specific area where the cytoplasmic membrane contacts the zona pellu...

journal_title：Reproductive biomedicine online

authors： Kellam L,Pastorelli LM,Bastida AM,Senkbeil A,Montgomery S,Fishel S,Campbell A

更新日期：2017-12-01 00:00:00

abstract：:The effect of increasing donor body mass index (BMI) on clinical pregnancies was retrospectively analysed in a cohort of consecutive 2722 donor oocyte IVF cycles. The relationship between donor BMI and clinical pregnancies was assessed after adjusting for recipient BMI. Clinical pregnancy rates and live birth rates (L...

journal_title：Reproductive biomedicine online

authors： Martínez F,Kava-Braverman A,Clúa E,Rodríguez I,Gaggiotti Marre S,Coroleu B,Barri PN

更新日期：2017-12-01 00:00:00

abstract：:Granulosa cells (GCs) play a major role in folliculogenesis and are crucial for oocyte maturation and growth. In these cells, the mTOR/AKT signalling pathway regulates early folliculogenesis by maintaining the dormancy of primordial follicles, while FSH induces their further differentiation and maturation. Because cha...

journal_title：Reproductive biomedicine online

authors： Rehnitz J,Alcoba DD,Brum IS,Hinderhofer K,Youness B,Strowitzki T,Vogt PH

更新日期：2017-11-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disease that involves menstrual dysfunction and reproductive difficulty, as well as metabolic problems. The aim of this study was to assess the effectiveness of myo-inositol (MYO) and d-chiro-inositol (DCI) on improving oocyte or embryo quality and pregna...

journal_title：Reproductive biomedicine online

authors： Mendoza N,Pérez L,Simoncini T,Genazzani A

更新日期：2017-11-01 00:00:00

abstract：:The use of donor sperm is increasing, yet limited information is available about the health and development of children conceived from donor sperm. This retrospective descriptive study aimed to assess health and development in a cohort of school-aged children who were conceived using donor sperm. Participants included...

journal_title：Reproductive biomedicine online

authors： Amor DJ,Lewis S,Kennedy J,Habgood E,McBain J,McLachlan RI,Rombauts LJ,Williams K,Halliday J

更新日期：2017-10-01 00:00:00

abstract：:The current systematic review and meta-analysis evaluate the perinatal outcomes in twin pregnancies following multifetal pregnancy reduction (MPR) compared with non-reduced triplet pregnancies. All studies comparing perinatal outcome of twin pregnancies following MPR to non-reduced triplet pregnancies were considered....

journal_title：Reproductive biomedicine online

authors： Zipori Y,Haas J,Berger H,Barzilay E

更新日期：2017-09-01 00:00:00